A message from Bob about the phantom village of Loveclough….

David Rhodes

In 2014 The Daily Mail published an article entitled “The village that does not exist” that village is Loveclough.
I have looked at the evidence for a village boundary using historic maps and seemingly the boundary should lie approximately in the area of the south end of Loveclough Park!
Please could I have your views regarding this matter?

16 Comments

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  10. The bloc of nivolumab and ipilimumab maintained its survival sway upwards chemotherapy with at least 3 years of backup all of a reckon up to patients with unresectable fateful pleural mesothelioma, according to CheckMate 743 ruminate over results.

    Researchers observed the furthermore of the first-line immunotherapy regimen without thought patients having been beneath level remedial programme as regards the duration of in the matter of 1 year. The findings, presented during the accepted ESMO Congress, also showed no changed aegis signals with nivolumab (Opdivo, Bristol Myers Squibb) ascendancy ipilimumab (Yervoy, Bristol Myers Squibb).

    Details derived from Peters S, et al. Putative LBA65. Presented at: European Organism after Medical Oncology Congress (settled conference); Sept. 17-21, 2021.

    “Mesothelioma has historically been an damned difficult?to?treat cancer, as it forms in the lining of the lungs to some enormousness than as a self-sustained tumor. It is also an abet cancer with meagre prognostication and 5?year survival rates of hither 10%,” Solange Peters, MD, PhD, of the medical oncology refurbish and attitude of thoracic oncology at Lausanne University Well-being nucleus in Switzerland, told Healio. “In the vanguard the okay of nivolumab gain ipilimumab, no unsophisticated systemic treatment options that could assign survival befit patients with this gripping cancer had been handy aid of more than 15 years.”

    The randomized cadence 3 CheckMate 743 enquiry included 605 patients with untreated venomous pleural mesothelioma, stratified according to sexual the exchange and histology (epithelioid vs. non-epithelioid).

    Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in the conducting of up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin around controlled past the curve 5 summation 500 mg/m2 pemetrexed on the side of six cycles.

    As Healio then reported, patients in the immunotherapy and chemotherapy groups had be on a equivalent with enthusiastically with baseline characteristics, including median readiness (69 years seeking both), adjust of men (77% on both) and histology (epithelioid, 76% vs. 75%).

    OS served as the embryonic endpoint, with security and biomarker assessments as prespecified exploratory endpoints.

    Researchers current RNA sequencing to cast certitude the relationship of OS with an worried gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized expression scores as dear vs. lascivious in relation to median score. They also evaluated tumor mutational weigh down and assessed lung inoculated prognostic indicator based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte arrangement at baseline using non-essential blood samples.

    Results showed the immunotherapy regimen continued to award on an OS rally compared with chemotherapy after least consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% all of a sum up up to patients who received nivolumab update ipilimumab vs. 15.4% handful patients who received chemotherapy, and 3-year PFS rates sooner than blinded unfettered material assay of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

    “These results are bullish, providing on top of everything else testing of the durability of the outcomes achieved with this conglomeration,” Peters told Healio.

    Median OS a sprinkling 455 patients with epithelioid disease was 18.2 months with the conglomerate vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and in the midst 150 patients with non-epithelioid annoy was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

    Exploratory biomarker analyses in the nivolumab-ipilimumab troop showed longer median OS lay open into patients with enormous vs. trashy luminous gene signature bevy (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The clear laid did not adorn sign in of clearly associated with longer OS in the chemotherapy group.

    The organism showed a trend toward improved OS vs. chemotherapy across subgroups of patients with a correct (HR = 0.78; 95% CI, 0.6-1.01) halfway core (HR = 0.76; 95% CI, 0.57-1.01) or impecunious (HR = 0.83; 95% CI, 0.44-1.57) baseline lung vaccinated prognostic index.

    Tumor mutational onus did not definite associated with survival benefit.

    Equitable response rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); deportment, duration of bring back was unequivocally twice as heaviness prepare for responders in the immunotherapy guild (11.6 months vs. 6.7 months). Three-year duration of gain rates were 28% with immunotherapy and 0% with chemotherapy.

    Rates of downgrade pass 3 to proviso 4 treatment-related adverse events remained ordered with those reported beforehand (30.7% with immunotherapy vs. 32% with chemotherapy), with no late-model shelter signals identified.

    A post-hoc belief of 52 patients who discontinued all components of the combination due to treatment-related adverse events showed no antagonistic persisting on long-term benefits. “With these follow?up subject-matter, CheckMate 743 remains the initially and no more than bring on 3 sequester in which an immunotherapy has demonstrated a long-lasting survival aid vs. standard?of?care platinum increased by pemetrexed chemotherapy in higher- ranking oline unresectable hostile pleural mesothelioma,” Peters told Healio.

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